Specificity of the LiMAx® test
The specificity of metabolism of hepatic 13C-methacetin was tested in the anhepatic phase during liver transplantation. There was no significant increase in delta-over-baseline (DOB) during the anhepatic phase, with negligible metabolization
Validation of the LiMAx® test
In a correlation analysis, linear correlations between the residual liver volume and the residual LiMAx were calculated
(figures 2 and 3).
Predictive value of the LiMAx® test
The multivariate analysis yielded LiMAx as the only predictor for postoperative liver failure (PLF) as well as for mortality after hepatectomy (table 1). The critical point for PLF was identified as postoperative LiMAx value < 85 μg/kg/h. Normal values from healthy volunteers were determined as LiMAx > 315 μg/kg/h.
After hepatectomy the LiMAx test allowed the early diagnosis of postoperative liver failure with better efficacy than other relevant laboratory markers.
Consistency of the LiMAx® cut-off
The normal range of the LiMAx value was found to be 430 ± 86 μg/kg/h at a cut-off at 315 μg/kg/h. Repetition of replicate LiMAx testing was 0.85 in healthy patients (95% CI, 0.69-0.93).
Stockmann, M. et al. Prediction of postoperative outcome after hepatectomy with a new bedside test for maximal liver function capacity. Ann. Surg. 250, 119–125 (2009)
Jara M. et al. Reliable assessment of liver function using LiMAx. J of Surgical Research 193, 184-189 (2015)